Hull York Medical School


Faculty of Science and Engineering University of Hull

 
  • Hannah Moody

    Supervisors - Professor Mike Lind, Dr Stephen Maher
    Location - School of Biological, Biomedical & Environmental Sciences, University of Hull
    Study - PhD

    Project Outline
    To investigate the role of small non-coding RNA molecules, namely microRNA, within context of mesothelioma.  My research hopes to explore the role of microRNA in mesothelioma chemoresistance.
  • Kai Wang

    Supervisors - Dr Justin Sturge, Dr Anne-Marie Seymour
    Location - School of Biological, Biomedical & Environmental Sciences, University of Hull
    Study - PhD

    Project Outline
    Investigating the biological and clinical implications of soluble Endo180 in breast cancer.  My project involves evaluation of Endo180 as a biomarker that can predict: (a) development of loco-regional recurrence and de novo metastasis in breast cancer patients; and (b) therapeutic response to bone-targeted therapies - bisphosphonates and denosumab - in advanced breast cancer patients.
  • Brittany J Wingham

    Supervisor - Dr Elena Rosca
    Location - 2nd Floor Allam Building, University of Hull
    Study - PhD

    Project Outline
    Our research involves investigating the activation status of dendritic cells in the tumour microenvironment.  My project aims to activate dendritic cells within the tumour via delivery of an activating peptide attached to liposome nanoparticles.  From here, we aim to develop a mathematical model to describe these interactions.
  • Becky Bibby

    Supervisor - Dr Stephen G Maher
    Location - Cancer, Biology & Therapeutics Lab, University of Hull
    Study - PhD

    Project Outline
    Analysis of miRNA espression in cell line models and pre-treatment biopsies identified significant down regulation of miR-330 and miR-187 in non-responders to neo-CRT.  The aim of my research is to examine the contributions of miR-187 and miR-330 to radioresistance and chemoresistance in oesophageal adenocarcinoma.
  • Flore-Anne Poujade

    Supervisor - Dr Isabel Pires
    Location - School of Biological, Biomedical and Environmental Sciences, University of Hull
    Study - PhD

    Project Outline
    My project aims to further the original observations identifying WSB-1 as a novel HIF1-dependant hypoxia-inducible gene and characterise it's role in hypoxia.  As it has recently been observed that WSB-1 may be involved in hypoxia-mediated cellular motility and tumour development, it is important to investigate whether WSB-1 expression is of prognostic value.

  • Nina Louise Purvis

    Supervisors - Dr Peter Gibbs, Dr Martin Pickles
    Location - The Centre of MR Investigations, Hull Royal Infirmary
    Study - PhD

    Project Outline
    A project with two arms: localisation and treatment.  Localisation - optimising MRI intra voxel incoherent motion imaging for feasible clinical scan times.  Treatment - investigating the physics and clinical oncological applications of magnetic resonance guided focused ultrasound (MRgFUS). 
  • Joanne Smith

    Supervisors - Dr Vicky Green, Professor John Greenman
    Location - 2nd Floor Daisy Building, Castle Hill Hospital
    Study - PhD

    Project Outline
    Our research looks at the effect of soluble factors released into the head and neck tumour microenvironment on the proliferation and function of immune cells; including T regulatory cells, T effector cells and cytotoxic T cells.
  • Ramsah Cheah

    Supervisors - Professor John Greenman, Dr Vicky Green
    Location - Medical Science, HYMS, Daisy Building, Castle Hill Hospital
    Study - PhD

    Project Outline
    Can the therapeutic response of early laryngeal tumours be predicted using a microfluidic based metabolomics approach?
  • Lily Oguh

    Supervisors - Dr Lynn Cawkwell, Professor Mike Lind
    Location - 2nd Floor Daisy Building, Castle Hill Hospital
    Study - PhD

    Project Outline
    Our research aims to explore molecular pathways associated with the hallmarks of cancer in the identification of novel therapeutic targets and biomarkers that predict response to chemotherapy in Malignant Pleural Mesothelioma.
  • Kapiraj Chandrabalan

    Supervisors - Professor Ross Boyle, Professor John Greenman, Dr Nicole Pamme
    Location - University of Hull
    Study - PhD

    Project Outline
    A microfluidic approach to the study of the cellular responses to oxidative stress. 

    It is known that reactive oxygen species (ROS) can be both useful and harmful to living organisms of all classes.  ROS are used by cells as signalling agents to mediate processes such as cell proliferation.  However excessive, uncontrolled ROS production can have negative effects such as DNA damage and lipid peroxidation, which have a role in diseases such as cancer, arthritis and arteriosclerosis.  This study investigates the effects of exposure of cells to defined levels of ROS using a microfluidic approach.
  • Chee Ching Chan

    Supervisors - Professor John Greenman, Professor Nick Stafford
    Location - 2nd Floor Daisy Building, Castle Hill Hospital
    Study - MSc

    Project Outline
    Analysis of head and neck squamous cell carcinoma tissue maintained in a microfluidic device following chemotherapy.
  • Mufuliat A Adesanya

    Supervisors - Professor Anthony Maraveyas, Dr Leigh Madden
    Location - 3rd Floor Allam Building, University of Hull
    Study - PhD

    Project Outline
    To study the expression levels of angiogenic soluble markers pre and post-treatment in patients; to study the levels of pre-operative MP in plasma and investigate quantitative changes of these before and after treatment and correlate results with cell invasion and angiogenesis; to correlate serological findings with immunohistochemical parameters such as VEGF, PDGF and TF; investigate whether serum from both cancers' patients contained higher absolute numbers of TF, CD 14 and annexin bearing MP than serum of the non-tumour control; correlate TF+MP number in vivo with in vitro pro-coagulant, cell invasion and angiogenic activities.