Dr Simon Hart is Senior Lecturer in Respiratory Medicine at Hull York Medical School and the University of Hull.
He graduated from Edinburgh University and trained in respiratory and general (internal) medicine in south-east Scotland. During his PhD he worked on neutrophil and macrophage biology and cell surface alterations associated with apoptosis (programmed cell death) in the MRC Centre for Inflammation Research, and in 2001 he was awarded an MRC Clinician Scientist fellowship.
He is Honorary Consultant in Respiratory Medicine at Castle Hill Hospital where he leads the Hull interstitial lung disease service and participates in the acute general medicine rota.
His research interests include the pathogenesis of idiopathic pulmonary fibrosis and other interstitial lung diseases, immunology of pulmonary fibrosis and sarcoidosis, and lung inflammation and repair.
Projects in our lab in the Daisy Clinical Research and Teaching Building (2nd floor), Castle Hill Hospital
We are using translational biology "bench to bedside" approaches to address challenges in pulmonary fibrosis and sarcoidosis.
1. Studies on the pathogenesis of idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is an incurable progressive scarring disease affecting the lungs of older people. We believe that development of effective therapies in the future will depend on a clear understanding of what initiates and perpetuates lung scarring. We have discovered abnormalities of platelet function in patients with IPF. We are also studying how the pulmonary vascular endothelium responds to injury and how these responses contribute to pulmonary fibrosis by promoting retention and activation of platelets in the lungs.
2. Immunological studies in sarcoidosis
Sarcoidosis is an inflammatory disease of unknown cause. Steroid treatment doesn't work well and side effects frequently outweigh benefits. We are studying immune responses in the blood samples of patients with sarcoidosis to help understand how the disease is driven.
Hart SP. Understanding CT patterns in idiopathic pulmonary fibrosis. Lancet Respir Med. 2014 Apr;2(4):249-50.
Fahim A, Crooks MG, Morice AH, Hart SP. Increased platelet binding to circulating monocytes in idiopathic pulmonary fibrosis. Lung. 2014 Apr;192(2):277-84.
Fahim A, Crooks MG, Wilmot R, Campbell AP, Morice AH, Hart SP. Serum carcinoembryonic antigen correlates with severity of idiopathic pulmonary fibrosis. Respirology. 2012;17:1247-52
Fahim A, Chong MC, Crooks MG, Hart SP. Idiopathic Pulmonary Fibrosis is Associated with Circulating Antiepithelial Antibodies. Lung. 2012;190:451-458
Hart SP, Rossi AG, Haslett C, Dransfield I. Characterization of the Effects of Cross-Linking of Macrophage CD44 Associated with Increased Phagocytosis of Apoptotic PMN. PLoS One. 2012;7(3):e33142
Fahim A, Crooks M, Hart SP. Gastroesophageal reflux and idiopathic pulmonary fibrosis: a review. Pulm Med. 2011;2011:634613. PubMed PMID: 21738875
Bournazos S, Bournazou I, Murchison JT, Wallace WA, McFarlane P, Hirani N, Simpson AJ, Dransfield I, Hart SP. Copy number variation of FCGR3B is associated with susceptibility to idiopathic pulmonary fibrosis. Respiration.2011;81:142-9.
Goh YC, Yap CT, Huang BH, Cronshaw AD, Leung BP, Lai PB, Hart SP, Dransfield I, Ross JA. Heat-shock protein 60 translocates to the surface of apoptotic cells and differentiated megakaryocytes and stimulates phagocytosis. Cell Mol Life Sci. 2011 68:1581-92.
Bournazos S, Bournazou I, Murchison JT, Wallace WA, McFarlane P, Hirani N, Simpson AJ, Dransfield I, Hart SP. Fcγ receptor IIIb (CD16b) polymorphisms are associated with susceptibility to idiopathic pulmonary fibrosis. Lung. 2010;188:475-81
Bournazos S, Grinfeld J, Alexander KM, Murchison JT, Wallace WA, McFarlane P, Hirani N, Simpson AJ, Dransfield I, Hart SP. Association of FcγRIIa R131H polymorphism with idiopathic pulmonary fibrosis severity and progression. BMC Pulm Med. 2010;10:51.
Bournazos S, Fahim A, Hart SP. Identification of fibrocytes in peripheral blood. Am J Respir Crit Care Med. 2009;180:1279
Bournazos S, Woof JM, Hart SP, Dransfield I. Functional and clinical consequences of Fc receptor polymorphic and copy number variants. Clin Exp Immunol. 2009;157:244-54
Bournazos S, Hart SP, Chamberlain LH, Glennie MJ, Dransfield I. Association of FcgammaRIIa (CD32a) with lipid rafts regulates ligand binding activity. J Immunol. 2009;182:8026-36
Kilpatrick DC, Chalmers JD, MacDonald SL, Murray M, Mohammed A, Hart SP, Matsushita M, Hill A. Stable bronchiectasis is associated with low serum L-ficolin concentrations. Clin Respir J. 2009 Jan;3:29-33.
Bournazos S, Rennie J, Hart SP, Fox KA, Dransfield I. Monocyte functional responsiveness after PSGL-1-mediated platelet adhesion is dependent on platelet activation status. Arterioscler Thromb Vasc Biol. 2008;28:1491-8.
Bournazos S, Rennie J, Hart SP, Dransfield I. Choice of anticoagulant critically affects measurement of circulating platelet-leukocyte complexes. Arterioscler Thromb Vasc Biol. 2008;28(1):e2-3
Hart SP, Dransfield I, Rossi AG. Phagocytosis of apoptotic cells. Methods 2008;44:280-285
Taylor EL, Rossi AG, Dransfield I, Hart SP. Analysis of neutrophil apoptosis. Methods Mol Biol. 2007;412:177-200